منابع مشابه
Phosphate and FGF-23
Fibroblast growth factor (FGF)-23 is probably the most important regulator of serum phosphate and calcitriol (1,25(OH)₂D₃) levels. It is secreted by osteocytes and osteoblasts in response to oral phosphate loading or increased serum 1,25(OH)₂D₃ levels. In human chronic kidney disease (CKD), plasma FGF-23 appears to be a sensitive biomarker of abnormal renal phosphate handling, as FGF-23 levels ...
متن کاملHCFMUSP FGF - 23 : state of the art
Approximately 10 years ago, a member of the family of the fibroblast growth factors, the hormone FGF-23 (fibroblast growth factor 23) was discovered. Its currently known functions involve phosphorus (P) metabolism and inhibition of 1α hydroxylase, the enzyme responsible for the synthesis of calcitriol. That discovery led to a better understanding of the mechanisms of P control, an element assoc...
متن کاملFGF-23 and Left Ventricular Hypertrophy
Submit Manuscript | http://medcraveonline.com cardiovascular health [1]. Among these FGFs, notably FGF-21 has shown cardio-protective effects such as improving lipoprotein profile, endothelial dysfunction and reducing plaque formation [1]. FGF-23; member of the FGF19 subfamily shows the highest degree of homology with FGF-21 [2,3]. However, contrary to FGF21, elevated levels of the bone-derived...
متن کاملPTH, FGF-23 and early CKD.
Patients with early CKD (GFR > 30 ml/min per 1.73 m2) do not usually have changes in the serum calcium and phosphate concentration. PTH may be minimally increased and more recent publications have shown that the phosphaturic hormone, FGF-23, is clearly increased. Thus in early CKD, serum levels of phosphate and calcium are maintained within normal levels because hormonal changes compensate for ...
متن کاملFGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone.
The functional interaction between fibroblast growth factor 23 (FGF-23) and Klotho in the control of vitamin D and phosphate homeostasis is manifested by the largely overlapping phenotypes of Fgf23- and Klotho-deficient mouse models. However, to date, targeted inactivation of FGF receptors (FGFRs) has not provided clear evidence for an analogous function of FGFRs in this process. Here, by means...
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ژورنال
عنوان ژورنال: Pflügers Archiv - European Journal of Physiology
سال: 2007
ISSN: 0031-6768,1432-2013
DOI: 10.1007/s00424-007-0231-5